Tuberculosis diagnosis publications

By September 29th, 2010

The following publications detail the work involved in the development of CSIRO’s Tuberculosis diagnosis in animals and humans using gamma interferon technology .


Wood PR, Corner LA, 1994, ‘In Vitro assay for detecting cell-mediated immune responses’, U.S. Patent Number 5,334,504.


Diel R, Loddenkemper R, Meywald-Walter K, Niemann S, Nienhaus A, 2008, ‘Predictive value of a whole blood IFN-gamma assay for the development of active tuberculosis disease after recent infection with Mycobacterium tuberculosis‘, Am. J. Respir. Crit. Care Med., 177: 1164-1170.

Gormley E, Doyle MB, Fitzsimons T, McGill K, Collins JD, 2006, ‘Diagnosis of Mycobacterium bovis infection in cattle by use of the gamma-interferon (Bovigam®) assay’, Vet. Micro., 112: 171-179.

Rothel JS, Andersen P, 2005, ‘Diagnosis of latent Mycobacterium tuberculosis infection: is the demise of the Mantoux test imminent?’, Expert Rev. Anti Infect. Ther., 3: 981-993.

Mori T, Sakatani M, Yamagishi F, Takashima T, Kawabe Y, Nagao K, Shigeto E, Harada N, Mitarai S, Okada M, Suzuki K, Inoue Y, Tsuyuguchi K, Sasaki Y, Mazurek GH, Tsuyuguchi I, 2004, ‘Specific detection of tuberculosis infection: an interferon-gamma based assay using new antigens’, Am. J. Respir. Crit. Care Med., 170: 59-64.

Buddle BM, Ryan TJ, Pollock JM, Andersen P, de Lisle GW, 2001, ‘Use of ESAT-6 in the interferon test for diagnosis of bovine tuberculosis following skin testing’, Vet. Micro., 80: 37-46.

Wood PR, Jones SL, 2001, ‘BOVIGAMâ„¢: An in vitro cellular diagnostic test for bovine tuberculosis’, Tuberculosis, 81: 147-155.

Neill SD, Pollock JM, 2000, ‘Testing for bovine tuberculosis — more than skin deep’, Vet. J., 160: 3-5.

Ryan TJ, Buddle BM, de Lisle GW, 2000, ‘An evaluation of the gamma interferon test for detecting bovine tuberculosis in cattle 8 to 28 days after tuberculin skin testing’, Res. Vet. Sci., 69: 57-61.

Desem N, Jones SL, 1998, ‘Development of a human gamma interferon enzyme immunoassay and comparison with tuberculin skin testing for detection of Mycobacterium tuberculosis infection’, Clin. Diag. Lab. Immunol., 5: 531-536.

Streeton JA, Desem N, Jones SL, 1998, ‘Sensitivity and specificity of a gamma interferon blood test for tuberculosis infection’, Int. J. Tuberc. Lung. Dis., 2: 443-450.

Neill SD, Cassidy J, Hanna J, Mackie DP, Pollock JMcA, Clements A, Walton E, Bryson TGD, 1994, ‘Detection of Mycobacterium bovis infection in skin test-negative cattle with an assay for bovine interferon-gamma’, Vet. Rec., 135: 134-135.

Wood PR, Rothel JS, 1994, ‘In vitro immunodiagnostic assays for bovine tuberculosis’, Vet. Micro., 40: 125-135.

Wood PR, Corner LA, Rothel JS, Baldock C, Jones SL, Cousins DB, McCormick BS, Francis BR, Creeper J, Tweddle NE, 1991, ‘Field comparison of the interferon-gamma assay and the intradermal tuberculin test for the diagnosis of bovine tuberculosis’, Aust. Vet. J., 68: 286-290.

Rothel JS, Jones SL, Corner LA, Cox JC, Wood PR, 1990, ‘A sandwich enzyme immunoassay for bovine interferon and its use for the detection of tuberculosis in cattle’, Aust. Vet. J., 67: 134-137.

Wood PR, Corner LA, Plackett P, 1990, ‘Development of a simple, rapid in vitro cellular assay for bovine tuberculosis based on the production of interferon’, Res. Vet. Sci., 49: 46-49.

Wood PR, Rothel JS, McWaters PGD, Jones SL, 1990, ‘Production and characterization of monoclonal antibodies specific for bovine gamma-interferon’, Vet. Immunol. Immunopath., 25: 37-46.