Bacterial drug resistance publications

By December 22nd, 2010

The following publications detail the work involved in the development of CSIRO’s Bacterial drug resistance, gene cassettes and integrons.

Key reviews

Hall RM, Collis CM, 1995, ‘Mobile gene cassettes and integrons: capture and spread of genes by site-specific recombination’, Molec. Microbiol., 15: 593-600.

Recchia GD, Hall RM, 1995, ‘Gene cassettes: a new class of mobile element’, Microbiol., 141: 3015-3027.

Key papers

Collis CM, Kim M-J, Stokes HW, Hall RM, 2002, ‘Integron-encoded integrases preferentially recognize the adjacent cognate attI site in recombination with a 59-be’, Molec. Microbiol., 46: 1415-1427.

Collis CM, Kim M-J, Stokes HW, Hall RM, 1998, ‘Binding of the purified integron DNA integrase, IntI1, to integron- and cassette-associated recombination sites’, Molec. Microbiol., 29: 477-490.

Stokes HW, O’Gorman DB, Recchia GD, Parsekhian M, Hall RM, 1997, ‘Structure and function of 59-base element recombination sites associated with mobile gene cassettes’, Molec. Microbiol., 26: 731-745.

Collis CM, Grammaticopoulos G, Briton J, Stokes HW, Hall RM, 1993, ‘Site-specific insertion of gene cassettes into integrons’, Molec. Microbiol., 9: 41-52.

Collis CM, Hall RM, 1992, ‘Site-specific deletion and rearrangement of integron insert genes catalysed by the integron DNA integrase’, J. Bacteriol., 174: 1574-1585.

Hall RM, Brookes DE, Stokes HW, 1991, ‘Site-specific insertion of genes into integrons: role of the 59-base element and determination of the recombination crossover point’, Molec. Microbiol., 5: 1941-1959.

Cameron FH, Groot Obbink DJ, Ackerman VP, Hall RM, 1986, ‘Nucleotide sequence of the AAD(2″) aminoglycoside adenylyltransferase determinant aadB. Evolutionary relationship of this region with those surrounding aadA in R538-1 and dhfrII in R388′, Nucleic Acids Res., 14: 8625-8635.


Hall RM, 2001, ‘Integrons’, In: Encyclopedia of Genetics, Brenner S, Miller JH (eds), Academic Press, London, pp.1041-1045.

Hall RM, 2001, ‘Gene cassettes’, In: Encyclopedia of Genetics, Brenner S, Miller JH (eds), Academic Press, London, pp.771-774.

Liebert CA, Hall RM, Summers AO, 1999, ‘Transposon Tn21, Flagship of the floating genome’, Microbiol. Mol. Biol. Rev., 63: 507-522.

Hall RM, Collis CM, 1998, ‘Antibiotic resistance in gram negative bacteria: the role of gene cassettes and integrons’, Drug Resistance Updates, 1: 109-119.

Recchia GD, Hall RM, 1997, ‘Origins of the mobile gene cassettes found in integrons’, Trends in Microbiol., 5: 389-394.

Hall RM, 1995, ‘Integrons: The movers and shakers of antibiotic resistance’, Today’s Life Science, 7: 38-44.

Hall RM, Stokes HW, 1993, ‘Integrons: novel DNA elements which capture genes by site-specific recombination’, Genetica, 90: 115-132.

Hall RM, 1989, ‘A new mechanism for the spread of antibiotic resistance genes’, Todays Life Sciences, 1: 30-38.

Book chapters

Hall RM, 2002, ‘Gene cassettes and integrons; moving single genes, In: Horizontal Gene Transfer, 2nd Edition, Syvanan M, Kado C (eds), Harcourt Publishing, London, pp.19-28.

Hall RM, Collis CM, 2001, ‘Origins and evolution of antibiotic and multiple antibiotic resistance in bacteria, In: Development of Novel Antimicrobial Agents: Emerging Strategies, Lohner K (ed), Horizon Scientific Press, Wymondham, UK, pp.17-30.

Hall RM, Partridge SR, 2001, ‘Evolution of multiple antibiotic resistance by acquisition of new genes, In: Antibiotic Resistance and Antibiotic Development, Hughes D, Andersson DI (eds), Harwood Academic Publishers, Netherlands, pp.37-51.

Hall RM, 1998, ‘The role of gene cassettes and integrons in the horizontal transfer of genes in gram negative bacteria, In: Horizontal Gene Transfer: Implications and Consequences, Syvanan M, Kado C (eds), Chapman Hall, London, pp.53-62.

Hall RM, 1997, ‘Mobile gene cassettes and integrons: moving antibiotic resistance genes in gram-negative bacteria, In: Antibiotic Resistance: Origins, Evolution, Selection and Spread, Wiley, Chichester (Ciba Foundation Symposium 207), pp.192-205.

Hall RM, Recchia GD, Collis CM, Brown HJ, Stokes HW, 1996, ‘Gene cassettes and integrons: moving antibiotic resistance genes in gram negative bacteria, In: Antibiotic Resistance: from Molecular Basics to Therapeutic Options, Amábile-Cuevas C (ed), R.G. Landes Company, pp.19-34.

Original papers

Evershed NJ, Levings RS, Wilson NL, Djordjevic SP, Hall RM, 2009, ‘Unusual class 1 integron-associated gene cassette configuration found in IncA/C plasmids from Salmonella enterica‘, Antimicrob. Agents Chemother., 53: 2640-2642.

Post V, Hall RM, 2009, ‘AbaR5, a large multiple antibiotic resistance region found in Acinetobacter baumannii‘, Antimicrob. Agents Chemother., 53: 2667-2671.

Post V, Hall RM, 2009, ‘Insertion Sequences in the IS1111 family that Target the attC Recombination Sites of Integron-associated Gene Cassettes’, FEMS Microbiol. Letts., 290: 182-187.

Levings RS, Djordjevic SP, Hall RM, 2008, ‘SGI2, a relative of Salmonella genomic island SGI1 with an independent origin’, Antimicrob. Agents Chemother., 52: 2529-2537.

Hall RM, 2007, ‘The antibiotic resistance gene cluster of pAPEC-O1-R’, Antimicrob. Agents Chemother., 51: 3461-3462.

Hall RM, Holmes AJ, Roy PH, Stokes HW, 2007, ‘What are superintegrons?’, Nature Rev. Microbiol. Comment, doi:10.1038/nrmicro1462-c1.

Levings RS, Partridge SR, Djordjevic SP, Hall RM, 2007, ‘SGI1K, a variant of the SGI1 genomic island carrying a mercury resistance region, in Salmonella enterica serovar Kentucky’, Antimicrob. Agents Chemother., 51: 317-323.

Post V, Recchia GD, Hall RM, 2007, ‘Detection of gene cassettes in Tn402-like class 1 integrons’, Antimicrob. Agents Chemother., 51: 3467-3468.

Elbourne LDH, Hall RM, 2006, ‘Gene cassette encoding a 3-N-aminoglycoside acetyltransferase in a chromosomal integron’, Antimicrob. Agents Chemother., 50: 2270-2271.

Levings RS, Lightfoot D, Djordjevic SP, Elbourne LDH, Hall RM, 2006, ‘New integron gene cassette encoding a trimethoprim-resistant DfrB-type dihydrofolate reductase’, Antimicrob. Agents Chemother., 50: 2863-2865.

Levings RS, Lightfoot D, Djordjevic SP, Hall RM, 2006, ‘New integron gene cassette linG encoding a lincosamide nucleotidyltransferase’, Antimicrob. Agents Chemother., 50: 3514-3515.

Gestal A, Partridge SR, Stokes HW, Hall RM, 2005, ‘Recombination between the dfrA12– orfF –aadA2 cassette array and an aadA1 gene cassette creates a hybrid cassette, aadA8b‘, Antimicrob. Agents Chemother., 49: 4771-4774.

Levings RS, Lightfoot D, Partridge SR, Hall RM, Djordjevic SP, 2005, ‘The genomic island SGI1 containing the multiple antibiotic resistance region of Salmonella enterica var. Typhimurium DT104 or variants of it is widely distributed in other S. enterica serovars’, J. Bacteriol., 187: 4401-4409.

Levings RS, Partridge SR, Lightfoot D, Hall RM, Djordjevic SP, 2005, ‘A New Integron-Associated Gene Cassette Encoding a 3-N-Aminoglycoside Acetyltransferase’, Antimicrob. Agents Chemother., 49: 1238-1241.

Partridge SR, Hall RM, 2005, ‘Correctly identifying the streptothricin resistance gene cassette’, J. Clin. Microbiol., 43: 4298-4300.

Partridge SR, Hall RM, 2005, ‘Gene cassettes potentially encoding fosfomycin resistance’, Antimicrob. Agents Chemother., 49: 860-861.

Collis CM, Hall RM, 2004, ‘Comparison of the structure activity relationships of the integron-associated recombination sites attI3 and attI1 reveals common features’, Microbiology., 150: 1591-1601.

Hall RM, Stokes, HW, 2004, ‘Integrons or super integrons?’, Microbiol., 150: 3-4.

Partridge SR, Hall RM, 2004, ‘Complex multiple antibiotic and mercury resistance region derived from the r-det of NR1 (R100)’, Antimicrob. Agents Chemother., 48: 4250-4255.

Partridge SR, Hall RM, 2003, ‘In34, a complex In5 family class 1 integron containing orf513 and dfrA10‘, Antimicrob. Agents Chemother., 47: 342-349.

Collis CM, Kim M-J, Partridge SR, Stokes HW, Hall RM, 2002, ‘Characterization of the class 3 integron and the site-specific recombination system it determines’, J. Bacteriol., 184: 3017-3026.

George AM, Hall RM, 2002, ‘Efflux of chloramphenicol by the CmlA1 protein’, FEMS Microbiol. Letts., 209: 209-213.

Partridge SR, Brown HJ, Hall RM, 2002, ‘Characterization and movement of the class 1 integron known as Tn2521 and Tn1405‘, Antimicrob. Agents Chemother., 46: 1288-1294.

Partridge SR, Collis CM, Hall RM, 2002, ‘Class 1 integron containing a new gene cassette, aadA10, associated with Tn1404 from R751′, Antimicrob. Agents Chemother., 46: 2400-2408.

Collis CM, Recchia GD, Kim M-J, Stokes HW, Hall RM, 2001, ‘Efficiency of recombination reactions catalysed by the class 1 integron integrase IntI1′, J. Bacteriol., 183: 2535-2542.

Partridge SR, Brown HJ, Stokes HW, Hall RM, 2001, ‘Transposons Tn1696 and Tn21 and their integrons In4 and In2 have independent origins’, Antimicrob. Agents Chemother., 45: 1263-1270.

Partridge SR, Recchia GD, Scaramuzzi C, Collis CM, Stokes HW, Hall RM, 2000, ‘Definition of the attI1 site of class 1 integrons’, Microbiology, 146: 2855-2864.

Partridge SR, Recchia GD, Stokes HW, Hall RM, 2001, ‘A family of class 1 integrons related to In4 from Tn1696‘, Antimicrob. Agents Chemother., 45: 3014-3020.

Hall RM, Collis CM, Kim M-J, Partridge SR, Recchia GD, Stokes HW, 1999, ‘Mobile gene cassettes and integrons in evolution’, In: Molecular strategies in biological evolution, Annals N.Y. Acad. Sci., 870: 68-80.

White PA, Stokes HW, Bunny KL, Hall RM, 1999, ‘Characterisation of a chloramphenicol acetyltransferase determinant found in the chromosome of Pseudomonas aeruginosa‘, FEMS Microbiol Letts., 175: 27-35.

Brown HJ, Stokes HW, Hall RM, 1996, ‘The integrons In0, In2, and In5 are defective transposon derivatives’, J. Bacteriol., 178: 4429-4437.

Bunny KL, Hall RM, Stokes HW, 1995, ‘New mobile gene cassettes containing an aminoglycoside resistance gene, aacA7, and a chloramphenicol resistance gene, catB3, in an integron in pBWH301′, Antimicrob. Agents Chemother., 39: 686-693.

Collis CM, Hall RM, 1995, ‘Expression of the antibiotic resistance genes in the integrated cassettes of integrons’, Antimicrob. Agents Chemother., 39: 155-162.

Recchia GD, Hall RM, 1995, ‘Plasmid evolution by acquisition of mobile gene cassettes: Plasmid pIE723 contains the aadB gene cassette precisely inserted at a secondary site in the IncQ plasmid RSF1010′, Molec. Microbiol., 15: 179-187.

Hall RM, Brown HJ, Brookes DE, Stokes HW, 1994, ‘Integrons found in different locations have identical 5′ ends but variable 3′ ends’, J. Bacteriol., 176: 6286-6294.

Recchia GD, Stokes HW, Hall RM, 1994, ‘Characterisation of specific and secondary recombination sites recognised by the integron DNA integrase’, Nucleic Acids Res., 22: 2071-2078.

Stokes HW, Parsons Y, Tomaras C, Hall RM, 1993, ‘The partial 3′ conserved segment duplications in the integrons In6 from pSa and In7 from pDGO100 have a common origin’, Plasmid., 30: 39-50.

Collis CM, Hall RM, 1992, ‘Gene cassettes from the insert region of integrons are excised as covalently closed circles’, Molec. Microbiol., 6: 2875-2885.

Stokes HW, Hall RM, 1992, ‘The integron In1 in plasmid R46 includes two copies of the oxa2 gene’, Plasmid, 28: 225-234.

Parsons Y, Hall RM, Stokes HW, 1991, ‘A new trimethoprim resistance gene, dhfrX, in the In7 integron of plasmid pDGO100′, Antimicrob. Agents Chemother., 35: 2436-2439.

Stokes HW, Hall RM, 1991, ‘Sequence analysis of the inducible chloramphenicol resistance determinant in the Tn1696 integron suggests regulation by translational attenuation’, Plasmid, 26: 10-19.

Hall RM, Stokes HW, 1990, ‘The structure of a partial duplication in the integron of plasmid pDGO100′, Plasmid, 23: 76-79.

Stokes HW, Hall RM, 1989, ‘A novel class of potentially mobile DNA elements encoding site specific gene insertion functions: integrons’, Mol. Microbiol., 3: 1669-1683.

Hall RM, Vockler C, 1987, ‘The region of the IncN plasmid R46 coding for resistance to β-lactam antibiotics, streptomycin/spectinomycin and sulphonamides is closely related to antibiotic resistance segments found in IncW plasmids and in Tn21-like transposons’, Nucleic Acids Res., 15: 7491-7501.