GM-CSF discovery publications

By September 23rd, 2010

The following publications detail the work involved in the development of CSIRO’s Granulocyte-macrophage colony stimulating factor discovery.


Dunn AR, Gough NM, Metcalf D, 1997, ‘Recombinant DNA molecules’, U.S. Patent Number 5,602,007 – Publication Number WO/1985/004188.

Key publications

Villeval JL, Duhrsen U, Morstyn G, Metcalf D, 1990, ‘Effect of recombinant human granulocyte-macrophage colony stimulating factor on progenitor cells in patients with advanced malignancies’, British Journal of Haematology, 74: 36-44.

Metcalf D, Begley CG, Johnson GR, Nicola NA, Vadas MA, Lopez AF, Williamson DJ, Wong GG, Clark SC, Wang EA, 1986, ‘Biologic properties in vitro of a recombinant human granulocyte-macrophage colony-stimulating factor’, Blood, 67: 37-45.

Sparrow LG, Metcalf D, Hunkapiller MW, Hood LE, Burgess AW, 1985, ‘Purification and partial amino acid sequence of asialo murine granulocyte-macrophage colony stimulating factor’, In: Proc. of the National Academy of Sciences, USA, 82: 292-296.

Gough NM, Gough J, Metcalf D, Kelso A, Grail D, Nicola NA, Burgess AW, Dunn AR, 1984, ‘Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte-macrophage colony stimulating factor’, Nature, 309: 763-767.


Metcalf D, 2000, Summon up the Blood – In dogged pursuit of the blood cell regulators, AlphaMed Press, Ohio, USA.


Metcalf D, 2008, ‘Hematopoietic cytokines’, Blood, 111: 485-491.

Metcalf D, 1999, ‘Cellular hematopoiesis in the twentieth century’, Seminars in Hematology, 36: 5-12.

Nicola NA, Smith A, Robb L, Metcalf D, Begley CG, 1997, ‘The structural basis of the biological actions of the GM-CSF receptor’, Ciba Foundation Symposia, 204: 19-32.

Metcalf D, 1990, ‘The colony stimulating factors, Discovery, development, and clinical applications’, Cancer, 65: 2185-2195.

Nicola NA, Metcalf D, 1986, ‘Specificity of action of colony-stimulating factors in the differentiation of granulocytes and macrophages’, Ciba Foundation Symposia, 118: 7-28.

Original papers

Burgess AW, Metcalf D, Sparrow LG, Simpson RJ, Nice EC, 1986, ‘Granulocyte/macrophage colony-stimulating factor from mouse lung conditioned medium: purification of multiple forms and radioiodination’, Biochemical Journal, 235: 805-814.

Burgess AW, Knesel J, Sparrow LG, Nicola NA, Nice EC, 1982, ‘Two forms of murine epidermal growth factor: rapid separation by using reverse-phase HPLC’, In: Proc. of the National Academy of Sciences, USA, 79: 5753-5757.